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Wednesday, May 6, 2020 | History

3 edition of Development and evaluation of novel liposomal formulations of antibiotics found in the catalog.

Development and evaluation of novel liposomal formulations of antibiotics

Clement Mugabe

Development and evaluation of novel liposomal formulations of antibiotics

by Clement Mugabe

  • 109 Want to read
  • 22 Currently reading

Published by Laurentian University, School of Graduate Studies in Sudbury, Ont .
Written in English


Edition Notes

Statementby Clement Mugabe.
The Physical Object
Paginationxiv, 112 l. :
Number of Pages112
ID Numbers
Open LibraryOL22233679M
ISBN 100494100052
OCLC/WorldCa175281940

  Rouf MA, Vural I, Renoir JM, Hincal AA. Development and characterization of liposomal formulations for rapamycin delivery and investigation of their antiproliferative effect on MCF7 cells. J Liposome Res. ; – doi: / [Google Scholar] The established in-house HPLC method for determination and quantification of CAM (Ingebrigtsen et al., ) was the starting point for the development of this novel HPLC change made was regarding the mobile phase, where the organic solvent was changed from methanol to acetonitrile, as BPO has poor stability in methanol and decomposes readily even at 25 °C (Hongo et al., ).

  Conclusion: The statistical factorial design of liposomal formulations fulfilled all the requirements of the target set and exhibited suitable values for the selected test parameters. Pastilles were prepared for liposomes using glycerol gelatin base and were found to be soft, smooth with uniform drug content and drug Liposomal formulations were developed using well-established rota-evaporation technique (Bhatia et al., ).In brief, various ratios of PC and CHOL with different concentrations of T were used ().PC, CHOL and T (total mass of mg) were dissolved in 10 mL chloroform-methanol mixture ( v/v) in a mL round bottom flask at room ://

1. Introduction. Most antifungal drug substances are lipophilic compounds, which are practically insoluble in water [].For skin care and the topical treatment of dermatological disease, a wide choice of vehicles ranging from solids to semisolids and liquid preparations is available to clinicians and patients [].Topical application of antimicrobial agents is a useful tool for the therapy of   This study aims to develop liposomal formulations containing synergistic antibiotics of colistin and ciprofloxacin for the treatment of infections caused by multidrug-resistant Pseudomonas aeruginosa. Colistin (Col) and ciprofloxacin (Cip) were co-encapsulated in anionic liposomes by ammonium sulfate gradient. Particle size, encapsulation efficiency, in vitro drug release and in vitro


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Development and evaluation of novel liposomal formulations of antibiotics by Clement Mugabe Download PDF EPUB FB2

Development and Stability Studies of Novel Liposomal Vancomycin Formulations Krishna Muppidi, 1 Andrew S. Pumerantz, 2 Jeffrey Wang, 1 and Guru Betageri 1 1 Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Liposomal formulations of anticancer agents have been developed to prolong drug circulating lifetime, enhance anti-tumor efficacy by increasing tumor drug deposition, and reduce drug toxicity by avoiding critical normal tissues.

Despite the clinical approval of numerous liposome-based chemotherapeutics, challenges remain in the development and clinical deployment of micro- and nano-particulate   Clinical development of liposome-based drugs: formulation, characterization, and therapeutic efficacy on the correlation of blood circulation time and drug accumulation in target tissues with physicochemical properties of liposomal formulations, including particle size, membrane lamellarity, surface charge, permeability, encapsulation These formulations were characterized and their behaviour was evaluated in one animal mal netilmicin formulations, prepared with the lipid composition phosphatidylcholine:cholesterol Radiation sterilization of antibiotic liposome formulations: A case study Article in Radiation Physics and Chemistry 76() August with 95 Reads How we measure 'reads' All araC-containing liposome formulations were found to be stable (liposomal araC showed significantly elevated cytotoxicity, with an IC 50 of 78 μM.

When 1 mM free folic acid was present during drug incubation, the cytotoxicity was reduced by ∼4-fold, with an IC 50 of μM The pH of ethosomal gels were evaluated and the value was found to be in range of ± and ± (Table 4). pH of all formulations lies between the normal physiological pH range of the skin, i.e., [25 Yusuf M, Sharma V, Pathak K.

Nanovesicles for transdermal delivery of felodipine: Development, characterization, and Vancomycin hydrochloride (VANH), the first glycopeptide antibiotic, is a water-soluble drug for the treatment of acute osteomyelitis.

Liposomal formulations of VANH have already been manipulated and characterized, which was a mean of increasing their therapeutic index, reducing their toxicity and altering drug :// Development of liposomal antibiotics for treatment of lung infections in cystic fibrosis patients under the supervision of Dr.

Abdel Omri. Thesis title: “Development and Evaluation of Novel Liposomal Formulations of Antibiotics”. Nowadays, the freeze-drying of liposome dispersions is still necessary to provide a solid dosage form intended for different routes of administration (i.e., parenteral, oral, nasal and/or pulmonary).

However, after decades of studies the optimization of process conditions remains still challenging since the freezing and the dehydration destabilize the vesicle organization with the concomitant   LIPOSOMES: A NOVEL DRUG DELIVERY SYSTEM Almost from the time of their discovery the demonstration of their entrapment potential, liposomal vesicles have drawn attention of researchers as potential carriers of various bioactive molecules that could be used for therapeutic applications.

targeting systems are currently under :// Application of a conventional lotion solution, a non-liposomal emulsion lotion and a liposomal emulsion lotion resulted in decreases ofand %, respectively, in the total number of Phytosterols are plant sterols recommended as adjuvant therapy for hypercholesterolemia and tocopherols are well-established anti-oxidants.

However, thermo-sensitivity, lipophilicity and formulation-dependent efficacy bring challenges in the development of functional foods, enriched with phytosterols and tocopherols. To address this, we developed liposomes containing brassicasterol   Topical delivery involves minimizing the flux of the drug through the skin while maximizing its retention on the skin.

The aim of the present work was the investigation of the effects of lipids and cholesterol for the development of liposomal formulations as In this article information about various methods of liposome preparation (including the large scale manufacture) has been reviewed. The advantages and disadvantages of the methods have been described in terms of size distribution and encapsulation :// Recent advances in liposomal dry powder formulations: Preparation and evaluation Article Literature Review in Expert Opinion on Drug Delivery 6(1) February with Reads   – Development of novel bio-relevant in vitro skin permeation tests (IVPT) using in-line flow through diffusion cells – Manufacture of AT-rated topical ointment formulations for in vitro Chapter 11 - Hydrogels as intrinsic antimicrobials.

yet the process for discovery and development of novel antimicrobials is lengthy and expensive, often lasting over 10 years and having a very limited successful yield. the authors suggested additional in vivo evaluations to prove the potential of the novel liposomal formulation ://   Purpose: To report tolerability, safety, and efficacy of a topical triamcinolone acetonide-loaded liposomes formulation (TA-LF) in targeting the macular area in patients with refractory pseudophakic cystoid macular edema (PCME).

Methods: For tolerability, safety and efficacy evaluation, 12 eyes of 12 patients with refractory PCME were exposed to one drop of TA-LF (TA at %) every 2 h for 90 We investigated the efficacy and safety of liposomal clarithromycin formulations with different surface charges against clinical isolates of Pseudomonas aeruginosa from the lungs of cystic fibrosis (CF) patients.

The liposomal clarithromycin formulations were prepared by the dehydration-rehydration method, and their sizes were measured using the dynamic-light-scattering ://.

The seminal work of Gertrude B. Elion and George H. Hitchings led to the development of agents such as the nucleobase 6-mercaptopurine and the   It has been reported that formulations of vesicular system lead to better result in the treatment of acne compared to conventional system by releasing the drug on targets in skin appendages and these systems are more suitable for lipophilic drug [14, 17].

Table 5 enlists the examples of various liposomal formulations used in ://   Misra A, Jinturkar K, Patel D, et al. () Recent advances in liposomal dry powder formulations: preparation and evaluation.

Expert Opin Drug Deliv Traini D and Young PM. () Delivery of antibiotics to the respiratory tract: an update. Expert Opin Drug Deliv 6: Kuhn RJ. () Formulation of aerosolized